Ondansetron 8 mg Tablet is used for the Prevention of nausea and vomiting associated with chemotherapy, radiotherapy, and postoperative settings.
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Safe with no harmful side effects.
Generally safe; limited human studies.
Probably safe; limited data.
Does not affect ability.
Safe with no dose adjustment needed.
Limited information; consult a doctor.
Blocks serotonin 5-HT3 receptors, preventing nausea and vomiting.
Emeren 8 belongs to a group of medications called 'anti-emetics primarily used in the prevention of vomiting (being sick) and nausea (feeling sick) that usually occur after cancer chemotherapy, radiation treatment, or surgery.
Ondansetron is a potent, highly selective 5HT3 receptor antagonist. Its precise mode of action in the control of nausea and vomiting is not known. Chemotherapeutic agents and radiotherapy may cause the release of 5HT in the small intestine initiating a vomiting reflex by activating vagal afferents via 5HT3 receptors. Ondansetron blocks the initiation of this reflex. Activation of vagal afferents may also cause a release of 5HT in the area postrema, located on the floor of the fourth ventricle, and this may also promote emesis through a central mechanism. Thus, the effect of ondansetron in the management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy is probably due to antagonism of 5HT3 receptors on neurons located both in the peripheral and central nervous system. The mechanisms of action in postoperative nausea and vomiting are not known but there may be common pathways with cytotoxic-induced nausea and vomiting.
Chemotherapy-Induced Nausea and Vomiting:
Adults and Pediatric Patients (6 months to 18 years):
Radiotherapy-Induced Nausea and Vomiting:
Adults:
Postoperative Nausea and Vomiting:
Adults:
Pediatrics:
Highly Emetogenic Chemotherapy:
Moderately Emetogenic Chemotherapy:
Pediatric (4-11 years):
Oral dissolving film is to be placed on the tongue and dissolved without chewing or swallowing whole.
Emeren 8 may cause a serious reaction when used with certain medicines like pain killers (acetaminophen, tramadol, ibuprofen), anti-anxiety (pregabalin, lorazepam), and antiparkinson medicine (apomorphine).
The use of Emeren 8 is restricted in people with hypokalemia (low potassium) and severe liver disease.
Contraindicated in patients known to have hypersensitivity to the drug or any of its components. Concomitant use of apomorphine.
Pregnancy:
Lactation:
Store this medicine at room temperature away from sunlight. Keep away from the reach of children and pets.
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